Profhilo H+L 2 ml 64 mg of hyaluronic acid unique bioremodeling facial filler


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Profhilo H+L 2 ml bioremodeling treatment

Profhilo is the first BDDE-free stabilised injectable hyaluronic acid (HA) based product for treating skin laxity.

PProfhilo® is not a dermal filler or biorevitaliser – Profhilo® has opened up a new injectable category – bioremodeling.
Thermal cross-linking changes the character and behavior of the HA resulting in the formation of co-operative hybrid complexes which modulate the tissues. This is also the explanation for the different biological behavior with respect to H-HA and L-HA alone. One of the main advantages is longevity. Hybrid cooperative complexes have proven to be very stable with natural hyaluronidase (BTH) digestion when compared to H-HA, widely used in biorevitalisation products, or L-HA alone resulting in the long-lasting release and the dual action of the two HA components. This dual action is ideal for remodeling skin laxity.

Profhilo system


In Profhilo®, L-HA is released slowly from the HA hybrid complexes and therefore does not trigger the first inflammatory cytokines making it very biocompatible. It also increas¬es patient comfort during and after treatment and provides hydration to the skin especially in the epidermis – the Hydro effect.

H-HA in Profhilo® provides a stable HA architecture in the dermis. This gives a volumetric effect – the Lift effect.

Another advantage of the stable co-operative hybrid complex when compared to H-HA and L-HA is the increase in the ex¬pression levels of type I and type III collagen in fibroblast and type IV and VII collagen in keratinocytes.

This results in improved skin quality and skin hydration both in the dermis and epidermis. There is also increased production of endogenous HA and elastin giving the skin a more youthful look.


Profhilo® contains 32mg of low molecular weight HA (80-100Kda) and 32 mg of high molecular weight HA (1100-1400Kda). This gives one of the highest concentration of HA on the market totalling 64 mg of HA in a 2ml prefilled syringe. Remarkably this can still be extruded using a 29g needle.

This hyaluronic based dermal filler is designed not only to fill wrinkles and fine lines, but also to treat skin laxity and to remodel and lift the face. In clinical studies, it is proven as an extremely effective anti-ageing product with dramatic effect in skin quality improvement even in most challenging areas such as the neck, perioral area, hands and arms. This unique injectable dermal filler creates volume in the tissue, where it is needed thanks to its high spreadability. The effect of Profhilo H+L is manifested in increased firmness and elasticity of the skin, overall facial rejuvenation with a real improvement in lines and tightness of the skin. No allergy test is needed prior to treatment due to the high biocompatibility of the product. 

5 points BAP injection technique:


To maximise the diffusion in the malar and sub-malar areas:

• The BAP were specifically chosen in anatomically respective areas
• The dilution phenomenon of the product itself
• 5 injections per side
• Reduced pain (slow injection)
• Lower possibility of bruising or hematoma
• Reduced number of treatment sessions
• Greater patient compliance

 Duration of the effect: 

The effect of Profhilo H+L dermal filler is non-permanent because the hyaluronic acid is completely broken down within the skin eventually leaving no trace of the filler. Usually the effect lasts about six months, but this period is determined by many factors such as skin type, age, lifestyle, the degree of correction required, the technique used by the practitioner, etc. 

For best results, two initial sessions are recommended, performed in one-month interval. After that further top up treatments may be prescribed to maintain the desired effect. 

Adverse effects: 

Minor side effects can occur at the implanted site in the form of discoloration, tenderness, itching, redness or discomfort. They disappear within several days after treatment. 


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